Mitigation of Radiation-induced Pneumonitis and Lung Fibrosis using Alpha-lipoic Acid and Resveratrol.
MouseRadiationFemalen = 25 mice in 5 groups, n = 5 per groupOral gavageAlpha-lipoic acid 200 mg/kg (1 ml of a 6 mg/ml solution in…Treatment began 24 hours after irradiation
Model: Chest (lung) irradiation with 18 Gy of cobalt-60 gamma rays (1.25 MeV) at a source to skin distance of 80 cm and a dose rate of 60 cGy per minute, under ketamine (20 mg/kg) and xylazine (5 mg/kg) anaesthesia
18 Gy lung irradiation caused severe pneumonitis and moderate fibrosis at 100 days. Alpha-lipoic acid and the combination mitigated most damage markers except collapse and lymphocyte infiltration. Resveratrol alone mitigated alveolar thickness, congestion, erythrocyte haemorrhage, oedema, neutrophi…
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