Biochemical and Echosonographic Impacts Using Siliphos-Selenium-Methionine-Alpha Lipoic Acid Plus Metformin Versus Metformin in Fatty Liver and Steatohepatitis
Liver Disease
Enrolment: 50 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Liver Disease
Enrolment: 50 · Results not recorded
Entrapment Neuropathy, Carpal Tunnel
Enrolment: 64 · Results not recorded
Obesity · Cardiovascular Disease · Type 2 Diabetes
Enrolment: 70 · Results not recorded
Schizophrenia · Oxidative Stress
Enrolment: 48 · Results not recorded
Adrenomyeloneuropathy
Enrolment: 13 · Results not recorded
COVID-19
Enrolment: 0 · Results not recorded
Obesity · Body Fat · Insulin Resistance
Enrolment: 103 · Results not recorded
Metabolic Syndrome · Obesity
Enrolment: 16 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Chest (lung) irradiation with 18 Gy of cobalt-60 gamma rays (1.25 MeV) at a source to skin distance of 80 cm and a dose rate of 60 cGy per minute, under ketamine (20 mg/kg) and xylazine (5 mg/kg) anaesthesia
18 Gy lung irradiation caused severe pneumonitis and moderate fibrosis at 100 days. Alpha-lipoic acid and the combination mitigated most damage markers except collapse and lymphocyte infiltration. Resveratrol alone mitigated alveolar thickness, congestion, erythrocyte haemorrhage, oedema, neutrophi…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Radiation-induced salivary gland injury from a single 18 Gy dose to the neck at 2 Gy/min using a 6 MV linear accelerator
ALA pretreatment preserved acinoductal integrity and salivary secretion and reduced oxidative stress, apoptosis, inflammation and fibrosis for at least 56 days after irradiation.
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Single and repetitive blast-induced traumatic brain injury (validated rodent blast model)
Alpha-lipoic acid prevented acute superoxide formation, increased antiapoptotic markers Bcl-2 (t = 3.079, P < 0.05) and haem oxygenase 1 (t = 8.169, P < 0.001) after single blast, reduced Bax (t = 4.483, P < 0.05), caspase 12 (t = 6.157, P < 0.001) and caspase 3 (t = 4.573, P < 0.01) and tau hyperp…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.