Gradually Increasing Tidal Volume May Mitigate Experimental Lung Injury in Rats.
RatEndotoxin/LPSWistarmalen = 64 ratsmechanical ventilationTidal volume 6 mL/kg control versus escalation to 22 mL/kg,…24 h after intratracheal lipopolysaccharide
Model: Intratracheal Escherichia coli lipopolysaccharide followed 24 h later by mechanical ventilation with different tidal volume escalation strategies
Shorter adaptation attenuated lung damage and interleukin-6 expression relative to no adaptation, whereas longer adaptation increased diffuse alveolar damage and heterogeneity and did not prevent injury.
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