THERAPY DOSSIER · th-178c4276d8b6

Gradual increase of mechanical ventilation tidal volume

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Endotoxin/LPS
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02386683 ↗Injury indicationNAcompleted

Intraoperative Lung-Protective Ventilation in Neurosurgery

Ventilator-induced Lung Injury

Enrolment: 360 · Results not recorded

NCT02871102 ↗NAterminated

Right-Sizing Tidal Volume in ARDS: Using the Stress Index to Optimize Mechanical Ventilation to Individual Respiratory Mechanics

Acute Respiratory Distress Syndrome

Enrolment: 4 · Results not recorded

NCT03288558 ↗NAunknown

Protective Mechanical Ventilation Strategy in Patients Undergoing Cardiac Surgery (VENT CARD)

Pulmonary Complications · Cardiac Surgery

Enrolment: 310 · Results not recorded

NCT03568786 ↗NAcompleted

Influence of the End-inspiratory Pause on Mechanical Ventilation and Its Correlation With Electrical Impedance Tomography

Anesthesia · Surgery

Enrolment: 32 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30870161 ↗2019Mixed findings

Gradually Increasing Tidal Volume May Mitigate Experimental Lung Injury in Rats.

RatEndotoxin/LPSWistarmalen = 64 ratsmechanical ventilationTidal volume 6 mL/kg control versus escalation to 22 mL/kg,…24 h after intratracheal lipopolysaccharide

Model: Intratracheal Escherichia coli lipopolysaccharide followed 24 h later by mechanical ventilation with different tidal volume escalation strategies

Shorter adaptation attenuated lung damage and interleukin-6 expression relative to no adaptation, whereas longer adaptation increased diffuse alveolar damage and heterogeneity and did not prevent injury.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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