PRECLINICAL PUBLICATION · 2019

Resveratrol attenuates doxorubicin-induced cardiotoxicity in rats by up-regulation of vascular endothelial growth factor B.

Rat / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Resveratrol

PMID 30857673 ↗2019Reported benefit

Resveratrol attenuates doxorubicin-induced cardiotoxicity in rats by up-regulation of vascular endothelial growth factor B.

RatChemical/toxinSprague-Dawleymalen = 40 rats, 10 per group across four groups

Model: Doxorubicin-induced cardiotoxicity

Resveratrol combined with doxorubicin attenuated cardiotoxicity and up-regulated VEGF-B, and small interfering RNA knockdown of VEGF-B abolished the protection.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.