Hyperbaric oxygen improves functional recovery of rats after spinal cord injury via activating stromal cell-derived factor-1/CXC chemokine receptor 4 axis and promoting brain-derived neurothrophic factor expression.
RatSpinal cord injuryContusionSprague-Dawleymalen = 60 rats, 15 per group across four groupshyperbaric chamber100 percent oxygen at 2.0 ATA for 1 h; AMD3100 5 mg/kg used…from postoperative day 0
Model: Contusive spinal cord injury by modified Allen method at T9, 10 g rod dropped from 5 cm onto a 2 mm circular zone, 10 s dwell
Hyperbaric oxygen significantly improved BBB scores from day 14 onwards and increased SDF-1, CXCR4 and BDNF expression, with benefit attenuated by the CXCR4 antagonist AMD3100.
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