The Effects of Hyperbaric Oxygen Therapy on Acute Thermal Burns
Acute Thermal Burns
Enrolment: 80 · Results not recorded
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Procedure
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acute Thermal Burns
Enrolment: 80 · Results not recorded
Acute Myeloid Leukemia · Acute Lymphoblastic Leukemia · Myelodysplastic Syndrome (MDS) · Hodgkins Lymphoma · Non-Hodgkins Lymphoma
Enrolment: 15 · Results not recorded
Cerebral Stroke
Enrolment: 0 · Results not recorded
Overweight and Obesity · Insulin Sensitivity
Enrolment: 12 · Results not recorded
RheumatoId Arthritis
Enrolment: 14 · Results not recorded
Healthy Lifestyle
Enrolment: 48 · Results not recorded
Fibromyalgia
Enrolment: 60 · Results not recorded
7 studies reported at therapy level; 17 evidence entries itemised.
Model: Contusive spinal cord injury by modified Allen method at T9, 10 g rod dropped from 5 cm onto a 2 mm circular zone, 10 s dwell
Hyperbaric oxygen significantly improved BBB scores from day 14 onwards and increased SDF-1, CXCR4 and BDNF expression, with benefit attenuated by the CXCR4 antagonist AMD3100.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Calf muscle contusion by modified mass-drop method; 640 g aluminium cylinder dropped from 250 mm onto a 10 mm hemispherical impactor over the medial calf
Hyperbaric oxygen improved tissue oxygenation, reduced early limb volume, wet weight and vascular permeability, increased regenerating myofibres and isometric strength at day 7, and shifted macrophage and satellite cell kinetics earlier via IL-6/STAT3.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Acute spinal cord injury
Hyperbaric oxygen significantly lowered MMP-2 at 72 h and MMP-9 at 48 h, 72 h and 5 days after injury, and reduced spinal cord oedema. MMP-2 and MMP-9 levels correlated positively with spinal cord water content.
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Model: Chronic constriction injury of the sciatic nerve
Rats showed transient allodynia immediately after hyperbaric oxygen, associated with changes in malondialdehyde and superoxide dismutase, while a single treatment produced a short-acting antinociceptive phase and repetitive treatment produced a long-acting antinociceptive phase with inhibition of a…
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Model: Acute experimental spinal cord injury; the specific injury procedure is not described in the retrieved abstract
Hyperbaric oxygen reduced HMGB1 mRNA and protein at days 7 and 14 (P<0.05) and NF-kappa B mRNA and protein at days 3, 7 and 14 (P<0.05), with a significant increase in the Basso, Beattie and Bresnahan score at days 7 and 14 (P<0.05).
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Model: Sciatic nerve crush with forceps for 10 s, repeated at 180 degrees for a further 10 s, under ketamine and xylazine anaesthesia
A single 60 min hyperbaric oxygen exposure at 3.5 ATA on day 7 restored mechanical thresholds to control levels and significantly increased the area under the curve relative to nerve crush alone. Continuous i.c.v. naltrexone completely blocked this anti-allodynic effect (F = 8.93, P = 0.0002), impl…
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Model: Sciatic nerve injury producing neuropathic pain in rats; clinical arm in patients with idiopathic trigeminal neuralgia
Repetitive hyperbaric oxygen greatly inhibited thermal hyperalgesia and mechanical allodynia and the associated neurochemical changes in rats, and produced rapid-onset, dose-dependent and long-lasting analgesia in patients with idiopathic trigeminal neuralgia.
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