PRECLINICAL PUBLICATION · 2019

CTHRC1 promotes wound repair by increasing M2 macrophages via regulating the TGF-beta and notch pathways.

Mouse / Wound

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Collagen triple helix repeat containing 1 (CTHRC1) protein

PMID 30849639 ↗2019Reported benefit

CTHRC1 promotes wound repair by increasing M2 macrophages via regulating the TGF-beta and notch pathways.

MouseWoundC57BL/6male

Model: Acute skin stab wound model, with a polyvinyl alcohol sponge model for macrophage characterisation

CTHRC1 accelerated acute wound healing and increased the M2 macrophage population and TGF-beta expression, effects attenuated by Notch pathway inhibition.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.