THERAPY DOSSIER · th-b1abe94ff133

Collagen triple helix repeat containing 1 (CTHRC1) protein

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04092244 ↗NAunknown

CTHRC1 as a new biomarker in diagnosis of rheumatoid arthritis

Rheumatoid Arthritis

Enrolment: 90 · Results not recorded

NCT04085471 ↗NAunknown

CTHRC1 as a promising biomarker in rheumatoid arthritis diagnosis

Rheumatoid Arthritis

Enrolment: 90 · Results not recorded

NCT04415502 ↗NAunknown

CTHRC1: a biomarker for evaluation of rheumatoid arthritis disease activity

Rheumatoid Arthritis

Enrolment: 100 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30849639 ↗2019Reported benefit

CTHRC1 promotes wound repair by increasing M2 macrophages via regulating the TGF-beta and notch pathways.

MouseWoundC57BL/6male

Model: Acute skin stab wound model, with a polyvinyl alcohol sponge model for macrophage characterisation

CTHRC1 accelerated acute wound healing and increased the M2 macrophage population and TGF-beta expression, effects attenuated by Notch pathway inhibition.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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