Acute Activation of alpha7-Nicotinic Receptors by Nicotine Improves Rodent Skin Flap Survival Through Nitrergic System.
RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyNot stated in abstract; co-administered agents given systemically0.5, 1, 1.5, 2 and 3 mg/kgacute pretreatment before flap elevation
Model: Random-pattern dorsal skin flap with caudal pedicle elevated at the midline
Nicotine at 1, 1.5 and 2 mg/kg significantly increased flap survival, an effect abolished by the alpha7 antagonist methyllycaconitine and by nitric oxide synthase inhibition and lost at higher doses.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.