Drug · Neuronal acetylcholine receptor alpha4/beta2 agonist (AGONIST)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Schizophrenia · Cognition Disorders
Enrolment: 32 · Results not recorded
Schizophrenia · Schizoaffective Disorder
Enrolment: 31 · Results not recorded
Smoking
Enrolment: 45 · Results not recorded
Smoking
Enrolment: 44 · Results not recorded
Smoking · Tobacco
Enrolment: 1280 · Results not recorded
Nicotine Use Disorder · Substance Use Disorders
Enrolment: 120 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Corneal alkali burn produced by placing 2 mm diameter Whatman #3 filter paper soaked in 1N NaOH on the central cornea for 40 seconds after topical 0.5% proparacaine hydrochloride, followed by rinsing with 25 ml of phosphate buffered saline, under Zoletil anaesthesia at 0.2 ml/kg intramuscularly
Chronic oral nicotine dose-dependently increased corneal neovascularisation at days 7 and 14 and upregulated VEGF, MMP9, alpha-SMA, TGF-beta and Col1 expression relative to vehicle, indicating accelerated angiogenic and fibrogenic responses after alkali injury.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Random-pattern dorsal skin flap with caudal pedicle elevated at the midline
Nicotine at 1, 1.5 and 2 mg/kg significantly increased flap survival, an effect abolished by the alpha7 antagonist methyllycaconitine and by nitric oxide synthase inhibition and lost at higher doses.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Blunt full-thickness transection of the left Achilles tendon with one week of plantarflexion casting
Nicotine impaired tendon healing. It slowed vascular inflow (increased rise time and reduced wash-in rate at 21 and 42 days), reduced vessel density at the injury site, altered gait (reduced braking force, rate of loading, stride width and speed) and increased passive ankle range of motion with red…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Chronic constriction injury of the sciatic nerve; separate neuropathy models induced by intravenous dideoxycytidine (25 mg/kg) and repeated intraperitoneal oxaliplatin (2.4 mg/kg)
Intraperitoneal nicotine reduced hypersensitivity to noxious and non-noxious stimuli after chronic constriction injury and reduced mechanical and thermal hypersensitivity in dideoxycytidine and oxaliplatin neuropathy models.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
