Evaluation of the Efficacy of Sildenafil Citrate Following Severe Head Trauma in an Experimental Rat Model.
RatTBIUnspecifiedWistar-derived albinofemalen = 28 rats, 7 per group across four groupsintraperitoneal10 mg/kgacute phase after injury
Model: Experimental severe head trauma (traumatic brain injury)
Sildenafil citrate significantly reduced pyknotic neuron counts and the pyknotic to total neuron ratio in both regions compared with untreated injury, with results similar to mannitol.
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