Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)GPR17iCreERT2:CAG-eGFP reporter miceMale
Model: Middle cerebral artery occlusion (MCAo)
Montelukast reduced ischaemic lesion evolution and atrophy, increased DTI-derived axial diffusivity and myelinated fibre number, raised myelin basic protein density and GSTpi-positive mature oligodendrocyte counts, rescued MCAo-induced impairment of cortical local field potentials, enhanced OPC rec…
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