Short- and Long Term Growth in Children With Asthma Treated With Budesonide or Montelukast
Asthma
Enrolment: 52 · Results not recorded
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Drug · Selective cysteinyl leukotriene receptor 1 (CysLT1) antagonist
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Asthma
Enrolment: 52 · Results not recorded
Asthma
Enrolment: 313 · Results not recorded
Rhinitis, Allergic, Seasonal
Enrolment: 1095 · Results not recorded
Healthy
Enrolment: 45 · Results not recorded
Healthy
Enrolment not recorded · Results not recorded
Asthma
Enrolment: 16 · Results not recorded
Covid19 · SARS-CoV-2 Infection
Enrolment: 150 · Results not recorded
Bronchiolitis · Wheezing · Cough
Enrolment: 146 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: transient middle cerebral artery occlusion focal cerebral ischaemia
Montelukast attenuated behavioural dysfunction, infarct volume, atrophy and neuron loss after focal cerebral ischaemia in mice and rats.
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Model: Middle cerebral artery occlusion (MCAo)
Montelukast reduced ischaemic lesion evolution and atrophy, increased DTI-derived axial diffusivity and myelinated fibre number, raised myelin basic protein density and GSTpi-positive mature oligodendrocyte counts, rescued MCAo-induced impairment of cortical local field potentials, enhanced OPC rec…
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Model: Hind limb skeletal muscle ischaemia-reperfusion produced by femoral artery clamping for 2 h followed by reperfusion
Montelukast-treated animals had significantly lower muscle malondialdehyde (p = 0.002) and significantly higher superoxide dismutase (p = 0.001) than ischaemia-reperfusion controls, with significantly less oedema, polymorphonuclear infiltration and erythrocyte extravasation on histopathology.
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