Diallyl sulfide ameliorates carbon tetrachloride-induced hepatotoxicity in rats via suppressing stress-activated MAPK signaling pathways.
RatChemical/toxinSprague-Dawley50, 100 and 200 mg/kgAdministered along with carbon tetrachloride
Model: Carbon tetrachloride-induced acute hepatotoxicity
Diallyl sulfide lowered serum aminotransferases, MDA, TNF-alpha, IL-1beta and MCP-1, restored HO-1, GSH and SOD, reduced NF-kappaB (p65), Bax, p38 MAPK and JNK expression, increased Nrf2 and Bcl-2, and reduced histological severity of hepatic damage.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.