Garlic Metabolism and Cytochrome P450 Modulation (garlic oil / allicin preparations)
Healthy
Enrolment: 80 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Healthy
Enrolment: 80 · Results not recorded
Histone Deacetylase (HDAC) Activity
Enrolment: 23 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Single whole body gamma irradiation (0.5 to 10 Gy, 60Co) causing acute colonic mucosal injury
Diallyl sulfide significantly inhibited colonic nuclear aberration formation across 0.5 to 10 Gy in a dose-related manner and suppressed the sustained induction of DNA synthesis and ornithine decarboxylase after 6 Gy. It was ineffective when given after irradiation, and difluoromethylornithine abol…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Carbon tetrachloride-induced acute hepatotoxicity
Diallyl sulfide lowered serum aminotransferases, MDA, TNF-alpha, IL-1beta and MCP-1, restored HO-1, GSH and SOD, reduced NF-kappaB (p65), Bax, p38 MAPK and JNK expression, increased Nrf2 and Bcl-2, and reduced histological severity of hepatic damage.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.