Efficacy and dermal toxicity analysis of Sildenafil citrate based topical hydrogel formulation against traumatic wounds.
RatWoundSprague-DawleyFemaleTopical
Model: Traumatic (excisional) skin wound
The sildenafil citrate hydrogel was stable and showed no acute dermal toxicity, and increased wound contraction, re-epithelialisation and tensile strength together with higher hydroxyproline, collagen, total protein and nitric oxide content. Histopathology confirmed enhanced re-epithelialisation, c…
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