Substance-P Prevents Cardiac Ischemia-Reperfusion Injury by Modulating Stem Cell Mobilization and Causing Early Suppression of Injury-Mediated Inflammation.
RatIschaemia-reperfusionCardiacSprague-DawleyMaleIntravenous injection
Model: Cardiac ischaemia-reperfusion injury and acute myocardial infarction
Substance P suppressed TNF-alpha induction while increasing IL-10, CD206+ monocytes and regulatory T cells in blood, reduced myocardial apoptosis at day 1, markedly stimulated CFU-e and CFU-f mobilisation, and improved cardiac contractility with smaller infarcts, less fibrosis and increased revascu…
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