Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Ischaemia-reperfusion · Wound · Other
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Preclinical/no trial
- ChEMBL max phase
- 1 / 4 (development scale, not regulatory approval)
- Synonyms
- Substance p; Neurokinin p; Neuropeptide sp-1; Substance p (1-11); Sh-oligopeptide-73
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 3
3 studies reported at therapy level; 3 evidence entries itemised.
RatIschaemia-reperfusionCardiacSprague-DawleyMaleIntravenous injection
Model: Cardiac ischaemia-reperfusion injury and acute myocardial infarction
Substance P suppressed TNF-alpha induction while increasing IL-10, CD206+ monocytes and regulatory T cells in blood, reduced myocardial apoptosis at day 1, markedly stimulated CFU-e and CFU-f mobilisation, and improved cardiac contractility with smaller infarcts, less fibrosis and increased revascu…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
RabbitWoundexogenous delivery to the wound
Model: Diabetic skin excisional wound in mice and rabbits, with additional substance P deficient and neurokinin-1 receptor deficient mouse models
Substance P treatment improved wound healing in diabetic mice and rabbits, while substance P or neurokinin-1 receptor deficiency impaired healing. Substance P bioavailability was reduced in diabetic skin and treatment restored an acute inflammatory response, allowing progression to the proliferativ…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
RatOtherSprague-DawleyIntraperitonealConcurrent with hyperoxia exposure
Model: Hyperoxia-induced acute lung injury (exposure to 95% O2 for up to 14 days)
Substance P significantly ameliorated hyperoxia-induced lung damage, decreased MDA, significantly increased SOD and markedly increased SHH expression compared with hyperoxia alone.
Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.
