Chronic electrical stimulation reduces hyperalgesia and associated spinal changes induced by peripheral nerve injury.
RatOtherFemalen = n=12 per group across four groups (untreated, repeated acut…Peripheral nerve electrical stimulation50 Hz, one hour per sessionDelivered during the two weeks following the lesion; acute stimulation given at…
Model: Sciatic nerve transection and repair
Repeated acute stimulation raised the mechanical pain threshold only transiently, whereas daily chronic stimulation reduced mechanical hyperalgesia until the end of follow-up, with the increasing-frequency protocol more sustained than constant 50 Hz. Chronic protocols restored dorsal horn beta2 adr…
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