THERAPY DOSSIER · th-47ae3477e029

Electrical stimulation (repeated acute, chronic constant 50 Hz, and increasing-frequency chronic protocols)

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 7

6 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01236976 ↗Injury indicationPHASE3completed

SCIPA Full-On: Intensive Exercise Program After Spinal Cord Injury (incl. FES-assisted cycling)

Spinal Cord Injury

Enrolment: 116 · Results not recorded

NCT00656149 ↗Injury indicationPHASE2/PHASE3completed

Outcome Evaluation of Exercise and Electrical Therapy for Quadriplegic Hand Function

Spinal Cord Injury · Quadriplegia · Tetraplegia

Enrolment: 13 · Results not recorded

NCT07583576 ↗Injury indicationNAnot yet recruiting

Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Paraplegia

Spinal Cord Injury · Paraplegia · Spasticity

Enrolment: 40 · Results not recorded

NCT07207798 ↗Injury indicationNArecruiting

Epidural Electrical Stimulation for Motor and Sensory Function Reconstruction in Spinal Cord Injury (T11-L3)

Spinal Cord Injuries

Enrolment: 10 · Results not recorded

NCT07164846 ↗Injury indicationNArecruiting

Effect of Neuro20 Functional Electrical Stimulation Suit on Autonomic Function, Muscle Performance, and Gait

Spinal Cord Injury · Stroke · Amputees

Enrolment: 30 · Results not recorded

NCT07101042 ↗Injury indicationNAnot yet recruiting

A Comparative Study of Cold and Paraspinal Stimulation on Erectile Dysfunction and Urinary Incontinence in SCI

Spinal Cord Injury

Enrolment: 30 · Results not recorded

NCT03453944 ↗NAunknown

Breath Synchronized Electrical Stimulation of the Abdominal Wall Muscles to Prevent Respiratory Muscle Atrophy

Mechanical Ventilation Complication · Muscle Weakness

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30786105 ↗2019Mixed findings

Chronic electrical stimulation reduces hyperalgesia and associated spinal changes induced by peripheral nerve injury.

RatOtherFemalen = n=12 per group across four groups (untreated, repeated acut…Peripheral nerve electrical stimulation50 Hz, one hour per sessionDelivered during the two weeks following the lesion; acute stimulation given at…

Model: Sciatic nerve transection and repair

Repeated acute stimulation raised the mechanical pain threshold only transiently, whereas daily chronic stimulation reduced mechanical hyperalgesia until the end of follow-up, with the increasing-frequency protocol more sustained than constant 50 Hz. Chronic protocols restored dorsal horn beta2 adr…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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