Propolis and Its Combination with Boric Acid Protect Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Oxidative Stress, Inflammation, DNA Damage, and Apoptosis in Rats.
RatIschaemia-reperfusionRenalSprague-DawleyIntragastric administrationPropolis 200 mg/kg; boric acid 14 mg/kg1 h before ischaemia
Model: Renal ischaemia-reperfusion (50 min ischaemia followed by 3 h reperfusion)
Propolis alone, and more markedly propolis combined with boric acid, improved functional parameters, increased the antioxidant response and reduced renal injury size and apoptosis, with lower MDA and TNF-alpha levels and reduced 8-OHdG formation compared with ischaemia-reperfusion alone.
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