THERAPY DOSSIER · th-10946f94b5fc

Propolis, alone and combined with boric acid

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04277182 ↗Injury indicationNAcompleted

Effect of Topical Turkish Propolis Application on Burn Healing in Experimental Burn Model

Burns · Burn Wound

Enrolment: 36 · Results not recorded

NCT00231218 ↗PHASE3completed

Effectiveness of Echinacea, Propolis and Vitamin C in Prevention of Respiratory Tract Infections and Gastroenteritis in Preschool Children

Common Cold · Gastroenteritis

Enrolment: 104 · Results not recorded

NCT04911335 ↗PHASE2completed

Safety and Efficacy of a Propolis-Based Product (FARINGEL PLUS) in Oral Mucositis in Palliative Care Patients

Oral Mucositis

Enrolment: 77 · Results not recorded

NCT06663995 ↗NAactive not recruiting

Locally Delivered Propolis Gel as an Adjunct to Nonsurgical Periodontal Therapy in Periodontitis

Periodontal Diseases

Enrolment: 32 · Results not recorded

NCT05183737 ↗NAactive not recruiting

Effects of Supplementation With Microcapsules of Turmeric and Propolis on Inflammatory Markers in Patients on Hemodialysis

Chronic Kidney Diseases · Inflammation

Enrolment: 34 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30783919 ↗2019Reported benefit

Propolis and Its Combination with Boric Acid Protect Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Oxidative Stress, Inflammation, DNA Damage, and Apoptosis in Rats.

RatIschaemia-reperfusionRenalSprague-DawleyIntragastric administrationPropolis 200 mg/kg; boric acid 14 mg/kg1 h before ischaemia

Model: Renal ischaemia-reperfusion (50 min ischaemia followed by 3 h reperfusion)

Propolis alone, and more markedly propolis combined with boric acid, improved functional parameters, increased the antioxidant response and reduced renal injury size and apoptosis, with lower MDA and TNF-alpha levels and reduced 8-OHdG formation compared with ischaemia-reperfusion alone.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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