Harnessing neurovascular interaction to guide axon growth.
MixedSpinal cord injuryHemisection / partialSprague-DawleyFemalen = 4 female adult Sprague-Dawley rats in total, each in vivo c…Surgical transplantation of the scaffold into the spinal cord hemisection cavityScaffold for transplantation: 2.5 mg/mL type I collagen, 3…Acute; day-2 scaffolds transplanted at the time of injury
Model: Acute cervical hemisection spinal cord injury created by aspiration at the level of the fourth cervical vertebra, 1 mm lateral of the midline from the posterior side
Microvessels aligned by interstitial fluid flow remained aligned in the rostral-caudal axis three weeks after transplantation and Tuj-1-positive host axons infiltrated the scaffold along them, with significantly greater axon alignment than static scaffolds, although microvessel and axon lengths did…
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