THERAPY DOSSIER · th-a30c45498629

Aligned microvessel scaffold (collagen, hyaluronan and Matrigel composite seeded with human cerebral microvascular endothelial cells and pericytes), transplanted into the hemisection cavity

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03966794 ↗Injury indicationPHASE1/PHASE2unknown

Functional Neural Regeneration Collagen Scaffold Transplantation Combined With Epidural Electrical Stimulation for Spinal Cord Injury Repair

Spinal Cord Injury

Enrolment: 9 · Results not recorded

NCT03933072 ↗Injury indicationPHASE1/PHASE2unknown

Functional Axon Regeneration in Complete Spinal Cord Injury Using Autologous Bulbar Olfactory Ensheathing Cells and Spinal Cord Bridging

Spinal Cord Injury C5-Th10 · Spinal Cord Transection

Enrolment: 2 · Results not recorded

NCT02510365 ↗Injury indicationPHASE1unknown

Safety and Efficacy of Functional Neural Regeneration Collagen Scaffold Transplantation in Complete Acute Spinal Cord Injury Patients

Acute Spinal Cord Injury

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30778117 ↗2019Reported benefit

Harnessing neurovascular interaction to guide axon growth.

MixedSpinal cord injuryHemisection / partialSprague-DawleyFemalen = 4 female adult Sprague-Dawley rats in total, each in vivo c…Surgical transplantation of the scaffold into the spinal cord hemisection cavityScaffold for transplantation: 2.5 mg/mL type I collagen, 3…Acute; day-2 scaffolds transplanted at the time of injury

Model: Acute cervical hemisection spinal cord injury created by aspiration at the level of the fourth cervical vertebra, 1 mm lateral of the midline from the posterior side

Microvessels aligned by interstitial fluid flow remained aligned in the rostral-caudal axis three weeks after transplantation and Tuj-1-positive host axons infiltrated the scaffold along them, with significantly greater axon alignment than static scaffolds, although microvessel and axon lengths did…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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