Delayed Captopril Administration Mitigates Hematopoietic Injury in a Murine Model of Total Body Irradiation.
MouseRadiationC57BL/6JFemalen = Survival studies n = 16 to 20 per group; haematology and se…Oral, dissolved in acidified drinking waterLow dose 0.065 g/L in drinking water, calculated maximal de…Initiated 1, 4, 6, 12, 24 or 48 h after total body irradiation
Model: Cobalt-60 gamma total body irradiation, 7.5 to 7.9 Gy at 0.615 Gy/min, haematopoietic acute radiation syndrome
Low-dose captopril (13 mg/kg/day) begun as late as 48 h after 7.9 Gy and continued for only 14 days raised 30-day survival to 62 per cent versus 6 to 12 per cent in vehicle controls, matching high-dose treatment. Survival was associated with recovery of bone marrow cellularity to about 90 per cent…
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