Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders.
MouseFractureTibiaC57BL/6 and Ccr2/Cx3cr1 reporter knock-in miceMalen = 111 C57BL/6 mice and 54 Ccr2/Cx3cr1 knock-in mice (165 in t…Intraperitoneal100 ng per mouse (2 micrograms/mL in saline with 0.14% etha…Prophylactic, given before skin incision
Model: Open stabilised tibia fracture of the left hind leg under isoflurane anaesthesia, with a 0.38 mm intramedullary pin and osteotomy, as a model of perioperative neurocognitive disorder
Pre-operative Maresin 1 reduced systemic pro-inflammatory cytokines and raised IL-10, prevented surgery-induced glial activation, claudin-5 loss and CCR2-positive macrophage infiltration into the hippocampus, and significantly improved 72 h contextual fear conditioning memory, with no significant e…
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