Two different melatonin treatment regimens prevent an increase in kidney injury marker-1 induced by carbon tetrachloride in rat kidneys.
RatChemical/toxinWistarMaleTwo regimens: pre-intoxication and post-intoxication
Model: Carbon tetrachloride-induced acute kidney injury
Both regimens preserved kidney function on standard serum parameters and prevented the carbon tetrachloride-induced rise in tissue KIM-1, matching the morphological findings. Only post-intoxication melatonin preserved total kidney antioxidant capacity, while pre-treatment preserved reduced glutathi…
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