Protective effects of febuxostat against paraquat-induced lung toxicity in rats: Impact on RAGE/PI3K/Akt pathway and downstream inflammatory cascades.
RatChemical/toxinWistarMaleOral15 mg/kgGiven concurrently with paraquat over the 14 day treatment period; precise timi…
Model: Paraquat-induced acute lung toxicity following a single intraperitoneal dose of paraquat 30 mg/kg
Febuxostat attenuated paraquat-induced lung injury by inhibiting xanthine oxidase activity and associated oxidative stress, downregulating the RAGE/PI3K/Akt pathway and suppressing beta-catenin and its downstream inflammatory mediators.
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