The Cardiotoxicity Induced by Arsenic Trioxide is Alleviated by Salvianolic Acid A via Maintaining Calcium Homeostasis and Inhibiting Endoplasmic Reticulum Stress.
MixedChemical/toxinBALB/c mice; Sprague-Dawley rats for isolation of adult ventricular myocytesMalen = 60 mice randomised into 4 groups (15 per group); in vitro 3…Intraperitoneal injection in vivo; bath perfusion in vitro3 mg/kg/day in vivo; 1 micromolar in the perfusate in vitroPretreatment, given 1 h before each arsenic trioxide dose in vivo and 10 min be…
Model: Arsenic trioxide cardiotoxicity induced by 2 mg/kg/day arsenic trioxide by tail vein injection for two weeks in vivo, and 100 micromolar arsenic trioxide for 20 min in isolated adult rat ventricular myocytes in vitro
Salvianolic acid A pretreatment restored the ejection fraction and fractional shortening reduced by arsenic trioxide, reduced myofibrillar loss and cardiomyocyte necrosis, lowered serum creatine kinase, aspartate aminotransferase and lactate dehydrogenase, restored catalase, glutathione peroxidase…
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