Effect of Food on Pharmacokinetics of Salvianolic Acid A in Healthy Subjects
Healthy
Enrolment: 14 · Results not recorded
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Nutraceutical · get_mechanism for CHEMBL457077 returned 0 records, an EXPLICIT NEGATIVE RESULT: ChEMBL curates no mechanism of action for salvianolic acid A. A separate search for 'salvianolic acid B' returned 0 ChEMBL hits, so only the A congener resolves; the source therapy is a mixture of salvianolic acids, so this is a PARTIAL identity match. max_phase 1, natural product, first_approval NULL in ChEMBL itself.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Healthy
Enrolment: 14 · Results not recorded
Neuropathy of Diabetes
Enrolment: 40 · Results not recorded
Diabetes
Enrolment: 24 · Results not recorded
Stroke
Enrolment: 1 · Results not recorded
Angina, Stable
Enrolment: 18 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Acute carbon monoxide poisoning by exposure to 3000 ppm carbon monoxide in a chamber at 8 L/min for 40 min, producing more than 70 per cent carboxyhaemoglobin
Salvianolic acid preserved hippocampal CA1 neurons (72 plus or minus 9 surviving neurons per field versus 58 plus or minus 10 with carbon monoxide alone, and not different from controls), whereas neuron density fell by 29 per cent with carbon monoxide and 63 per cent with mannitol. It also prevente…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: middle cerebral artery occlusion and reperfusion-induced ischaemic stroke
Salvianolic acid A at 50 and 100 microgram/kg intravenously given 2 h after MCAO enhanced survival, improved moving activity and reduced brain infarction and apoptosis by limiting blood-brain barrier breakdown, nitrosative stress and NF-kB p65 and p25/Cdk5 activation, and promoted neurogenesis prot…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Arsenic trioxide cardiotoxicity induced by 2 mg/kg/day arsenic trioxide by tail vein injection for two weeks in vivo, and 100 micromolar arsenic trioxide for 20 min in isolated adult rat ventricular myocytes in vitro
Salvianolic acid A pretreatment restored the ejection fraction and fractional shortening reduced by arsenic trioxide, reduced myofibrillar loss and cardiomyocyte necrosis, lowered serum creatine kinase, aspartate aminotransferase and lactate dehydrogenase, restored catalase, glutathione peroxidase…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.