Effect of Hydrogen Sulfide on Kidney Injury in Rat Model of Crush Syndrome.
RatCrushLimb / muscle crushWistarMalen = 6 groups of 8 rats (48 in total)Intraperitoneal injection100 micromol/kg
Model: Crush syndrome produced by 6 h of direct compression of both hindlimbs of anaesthetised rats with 3.6 kg blocks on each side, followed by 3 or 24 h of decompression
Sodium hydrosulfide reduced renal kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, tumour necrosis factor alpha, transforming growth factor beta and total oxidant status while increasing total antioxidant status at both 3 and 24 h after decompression. Serum urea, creatinine and…
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