Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Crush · Haemorrhage/shock
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 3
3 studies reported at therapy level; 3 evidence entries itemised.
RatCrushLimb / muscle crushWistarMalen = 6 groups of 8 rats (48 in total)Intraperitoneal injection100 micromol/kg
Model: Crush syndrome produced by 6 h of direct compression of both hindlimbs of anaesthetised rats with 3.6 kg blocks on each side, followed by 3 or 24 h of decompression
Sodium hydrosulfide reduced renal kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, tumour necrosis factor alpha, transforming growth factor beta and total oxidant status while increasing total antioxidant status at both 3 and 24 h after decompression. Serum urea, creatinine and…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
RatHaemorrhage/shockUnspecifiedWistarMaleIntraperitoneal injection5.6 mg/kgFirst dose 2 h after subarachnoid haemorrhage
Model: Experimental subarachnoid haemorrhage with early brain injury and secondary cognitive deficits
NaHS reduced brain oedema and neuronal death, improved neurobehavioural function at 48 h and improved Morris water maze learning and memory at 7 days, with a lower Bax/Bcl-2 ratio, suppressed caspase-3 activation and increased phospho-Akt, phospho-ERK, BDNF and phospho-CREB.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
RatCrushSpinal crushSprague-DawleyMalen = 162 rats randomly allocated to three groupsIntraperitoneal20 micromol/kg body weight
Model: Cauda equina compression by implanting silicone gel (10 x 1 x 1 mm) into the epidural spaces at L5 and L6; laminectomy at L4 in sham
Hydrogen sulfide treatment improved myelin sheath and cauda equina fibre morphology and reduced the number of TUNEL positive cells relative to compression alone, and the authors concluded it reduced oxidative stress and was neuroprotective.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
