Oral Ibuprofen Interferes with Cellular Healing Responses in a Murine Model of Achilles Tendinopathy.
MouseOtherC57Bl/6Malen = Histology n = 3 ankle joints per group; qPCR performed on p…Oral, ad libitum in drinking water1 mg/mL in drinking water, giving an average intake of appr…Early regimen started 3 days after injury; late regimen started 9 days after in…
Model: Unilateral TGF-beta1-induced Achilles tendinopathy, with 100 ng active recombinant human TGF-beta1 injected into the mid-portion of the Achilles tendon on days 0 and 2
Ibuprofen blocked remodelling of the inflammatory hyaluronan matrix, induced aberrant vasculogenic cell groups and abnormal gene activation at day 28, and reduced tensile stiffness (p = 0.004) and elastic modulus (p = 0.012) in mice dosed from day 3 to day 25 whether injured or not.
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