Human Tendon-Derived Collagen Hydrogel Significantly Improves Biomechanical Properties of the Tendon-Bone Interface in a Chronic Rotator Cuff Injury Model.
RatOtherSprague-DawleyInjection at the repair siteAt the time of surgical repair, 8 weeks after supraspinatus tendon resection
Model: Chronic rotator cuff injury created by bilateral resection of the supraspinatus tendons, with transosseous suture repair of both shoulders 8 weeks later
Hydrogel injection produced greater load to failure, stiffness, energy to failure, strain at failure and toughness and a significantly larger area of new cartilage than suture alone, with no significant difference in bone morphometry.
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