THERAPY DOSSIER · th-babf1ed11fa2

Injectable thermoresponsive type I collagen-rich decellularised human tendon-derived hydrogel

Biologic · Injectable decellularised human tendon-derived type-I-collagen hydrogel; biomaterial.

Evidence & regulatory context

Mechanism: Injectable decellularised human tendon-derived type-I-collagen hydrogel; biomaterial.
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30685142 ↗2019Reported benefit

Human Tendon-Derived Collagen Hydrogel Significantly Improves Biomechanical Properties of the Tendon-Bone Interface in a Chronic Rotator Cuff Injury Model.

RatOtherSprague-DawleyInjection at the repair siteAt the time of surgical repair, 8 weeks after supraspinatus tendon resection

Model: Chronic rotator cuff injury created by bilateral resection of the supraspinatus tendons, with transosseous suture repair of both shoulders 8 weeks later

Hydrogel injection produced greater load to failure, stiffness, energy to failure, strain at failure and toughness and a significantly larger area of new cartilage than suture alone, with no significant difference in bone morphometry.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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