Preventive Effect of Alkaloids from Lotus Plumule on Acute Liver Injury in Mice.
MouseChemical/toxinSPF KMMalen = 60 mice in six groups, 10 mice per groupOral gavage400 mg/kgProphylactic; CCl4 given 1 h after the final gavage on day 10
Model: Carbon tetrachloride-induced acute liver injury, 0.8% CCl4 in vegetable oil injected intraperitoneally at 0.1 mL/10 g
All three regional lotus plumule alkaloid preparations lowered liver index, serum AST, ALT and total bilirubin and hepatic MDA, raised SOD activity and antioxidant gene expression, and reduced histological necrosis, with efficacy close to silymarin.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.