Evidence & regulatory context
- Mechanism
- Crude alkaloid fraction; no ChEMBL entity for the fraction. Searched liensinine, neferine and lotus plumule: the only hit (NCT07678359, ZenRest lotus seed and rice germ extract blend, sleep quality in menopausal women) uses lotus SEED, a different plant part with no bisbenzylisoquinoline alkaloid characterisation, so it was deliberately not recorded.
- Target
- Not recorded
- Injury models
- Chemical/toxin
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseChemical/toxinSPF KMMalen = 60 mice in six groups, 10 mice per groupOral gavage400 mg/kgProphylactic; CCl4 given 1 h after the final gavage on day 10
Model: Carbon tetrachloride-induced acute liver injury, 0.8% CCl4 in vegetable oil injected intraperitoneally at 0.1 mL/10 g
All three regional lotus plumule alkaloid preparations lowered liver index, serum AST, ALT and total bilirubin and hepatic MDA, raised SOD activity and antioxidant gene expression, and reduced histological necrosis, with efficacy close to silymarin.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
