Vitamin D improves sunburns by increasing autophagy in M2 macrophages.
MouseRadiationC57BL/6J; myeloid-specific Atg7 conditional knockout (Atg7 floxed crossed with LysM-Cre) with floxed littermate controlsFemale for wild-type experiments; both sexes for the conditional knockout lineIntraperitoneal5 ng per intraperitoneal injection; 3-methyladenine used at…1 h following UV exposure
Model: Single UVB dose of 100 mJ/cm2 to a 2 cm2 depilated area of dorsal skin, producing acute sunburn-type injury
A single 5 ng intraperitoneal dose of vitamin D 1 h after UVB reduced wound area, tissue damage, inflammatory gene expression and apoptosis and expanded M2 macrophages, with protection lost when autophagy was blocked pharmacologically or by myeloid Atg7 deletion.
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