Preclinical studies of ropivacaine extended-release from a temperature responsive hydrogel for prolonged relief of pain at the surgical wound.
RatWoundSprague-DawleyMaleLocal administration at the injection siteRopivacaine 0.75%
Model: Surgical wound model of postoperative pain
PF-72 hydrogel retained ropivacaine locally with roughly twofold higher target tissue exposure and lower systemic peak concentrations, giving effective pain relief for at least 24 h.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.