Trial title not recorded
Chronic Pain · Ankle Fracture Surgery
Enrolment: 14 · Results not recorded
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Procedure · Sodium channel alpha subunit blocker (BLOCKER)
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Chronic Pain · Ankle Fracture Surgery
Enrolment: 14 · Results not recorded
Amputation
Enrolment: 62 · Results not recorded
Surgery · Renal Cancer
Enrolment: 20 · Results not recorded
Post Operative Pain
Enrolment: 80 · Results not recorded
Neuromuscular Blockade
Enrolment: 20 · Results not recorded
Arterial Occlusive Diseases
Enrolment: 56 · Results not recorded
Major Ankle Surgery
Enrolment: 50 · Results not recorded
Nerve Block
Enrolment: 56 · Results not recorded
Osteoarthritis, Knee
Enrolment: 40 · Results not recorded
Popliteal Sciatic Nerve Block
Enrolment: 80 · Results not recorded
Pain, Postoperative · Osteoarthritis, Knee
Enrolment: 78 · Results not recorded
Hip Arthroplasty Replacement · Post Operative Pain, Acute
Enrolment: 50 · Results not recorded
Knee Arthroscopy Surgery
Enrolment: 48 · Results not recorded
Laparoscopic Cholecystectomy
Enrolment: 100 · Results not recorded
Postoperative Analgesia
Enrolment: 120 · Results not recorded
Cesarean Section · Post Operative Pain
Enrolment: 52 · Results not recorded
Lobectomy
Enrolment: 118 · Results not recorded
Postoperative Pain
Enrolment: 68 · Results not recorded
Pain, Postoperative
Enrolment: 110 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Plantar surgical incision (hind paw) under anaesthesia
The block transiently raised mechanical and thermal thresholds for 2 hours only, with no change from 3 hours onwards, but significantly increased neutrophil infiltration and macrophage clearance of apoptotic cells and up-regulated TNF-alpha, prostaglandin E2, lipoxygenase-15 and haem oxygenase-1 at…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Surgical wound model of postoperative pain
PF-72 hydrogel retained ropivacaine locally with roughly twofold higher target tissue exposure and lower systemic peak concentrations, giving effective pain relief for at least 24 h.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Isolated perfused lung with acute increases in left atrial pressure, and in vivo acute hypertension induced by noradrenaline
Ropivacaine prevented pressure-induced increases in the lung filtration coefficient, pulmonary oedema and nitric oxide production without altering pulmonary haemodynamics.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.