Topical Corticosteroid Pretreatment Mitigates Cellular Damage After Caustic Injury to the Nasal Upper Airway Epithelium.
MouseChemical/toxinC57Bl/6FemaleTopical intranasalProphylactic, given prior to a single topical exposure to trichloroacetic acid
Model: Single intranasal topical exposure to trichloroacetic acid causing caustic injury of the nasal epithelium
Prophylactic topical budesonide preserved epithelial thickness and cell survival and reduced epithelial and cellular changes at 6 days compared with the other exposure groups.
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