Onset of Effect With Symbicort (budesonide/formoterol) vs Seretide in Severe COPD
COPD
Enrolment: 442 · Results not recorded
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Drug · Budesonide: Glucocorticoid receptor agonist (AGONIST); combined with formoterol, a long-acting beta2-agonist
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
COPD
Enrolment: 442 · Results not recorded
Bronchopulmonary Dysplasia
Enrolment: 108 · Results not recorded
Chronic Lung Disease of Prematurity
Enrolment: 25 · Results not recorded
Asthma
Enrolment: 20 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Acute pulmonary inflammation induced by a single 60 min whole-body inhalation exposure to nebulised 0.1% cadmium chloride solution, with animals killed 24 h later
High concentrations of inhaled budesonide or formoterol alone reduced cadmium-induced neutrophilic inflammation, lung injury scores and MMP-9 activity, whereas low concentrations alone were largely ineffective, but combining the two ineffective low concentrations produced a potentiated protective e…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.
Model: Single intranasal topical exposure to trichloroacetic acid causing caustic injury of the nasal epithelium
Prophylactic topical budesonide preserved epithelial thickness and cell survival and reduced epithelial and cellular changes at 6 days compared with the other exposure groups.
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.