Renal chymase-dependent pathway for angiotensin II formation mediated acute kidney injury in a mouse model of aristolochic acid I-induced acute nephropathy.
MouseChemical/toxinC57BL/6Femalen = Five groups, n=9 per group, 45 miceIntraperitonealCaptopril 10 mg/kg per day and chymostatin 10 mg/kg per day…Concurrent with the 3-day aristolochic acid dosing
Model: Aristolochic acid I-induced acute nephropathy, 15 mg/kg per day intraperitoneally for 3 days to a cumulative dose of 45 mg/kg
Chymase inhibition, and particularly combined ACE and chymase inhibition, lowered renal angiotensin II, reduced serum blood urea nitrogen and creatinine, proteinuria, inflammatory cytokines and tubular injury, and reduced p-MEK/p-ERK1/2 activation, though injury was ameliorated rather than prevente…
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