Acute N-Acetylcysteine Administration Ameliorates Loss of Olfactory Neurons Following Experimental Injury In Vivo.
MouseOtherC57BL/6n = n=4-6 mice per groupIntraperitoneal100 mg/kg twice daily, prepared at 5 mg/ml in phosphate buf…Initiated within 30 min after the surgical procedure
Model: Unilateral olfactory bulbectomy by craniotomy and aspiration of the right olfactory bulb, causing retrograde degeneration of mature olfactory sensory neurons
N-acetylcysteine-treated bulbectomised mice retained 54 plus or minus 8.1 mature neurons per 0.5 mm epithelium versus 28 plus or minus 4.2 in vehicle controls (p = 0.02), with no significant change in proliferation or apoptosis markers.
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