Effects of Diet on Late Radiation Injuries in Rats.
RatRadiationWAG/RijCmcrMale for the nephropathy model and female for the pneumonitis modeln = Initial nephropathy study 10 on AIN-76A versus 8 on Teklad…Oral, in the dietApproximately 18% protein by weight, fed ad libitumSwitched 1 week after irradiation in the mitigation arm; a separate arm switche…
Model: Leg-out partial-body irradiation with 320 kV x-rays at 11 Gy midline for radiation nephropathy, and whole-thorax irradiation at 12.75 Gy mid-lung for radiation pneumonitis
Switching to the AIN-76A diet after irradiation markedly reduced radiation nephropathy and non-significantly reduced pneumonitis morbidity, whereas switching before irradiation had no effect and the protein source did not matter.
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