THERAPY DOSSIER · th-1d44940f491a

Modified AIN-76A refined diet, with casein or isolated soy protein

Nutraceutical · Defined rodent purified diet; no ChEMBL entity. No trial tests the AIN-76A formulation itself; evidence recorded is protein-source-level (isolated soy protein, casein fraction) in human dietary studies.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Defined rodent purified diet; no ChEMBL entity. No trial tests the AIN-76A formulation itself; evidence recorded is protein-source-level (isolated soy protein, casein fraction) in human dietary studies.
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00067678 ↗PHASE1/PHASE2completed

Soy protein in early diabetic nephropathy

Diabetic Nephropathy · Diabetes Mellitus

Enrolment not recorded · Results not recorded

NCT02180841 ↗NAcompleted

Effect of soy protein powder (25 g/d and 50 g/d) on HDL-C function, central blood pressure and arterial stiffness

Cardiovascular Disease

Enrolment: 20 · Results not recorded

NCT02832700 ↗NAcompleted

Casein glycomacropeptide in healthy subjects: anti-inflammatory and microbiome-modulating effects

Gastrointestinal Disease

Enrolment: 24 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30624356 ↗2019Reported benefit

Effects of Diet on Late Radiation Injuries in Rats.

RatRadiationWAG/RijCmcrMale for the nephropathy model and female for the pneumonitis modeln = Initial nephropathy study 10 on AIN-76A versus 8 on Teklad…Oral, in the dietApproximately 18% protein by weight, fed ad libitumSwitched 1 week after irradiation in the mitigation arm; a separate arm switche…

Model: Leg-out partial-body irradiation with 320 kV x-rays at 11 Gy midline for radiation nephropathy, and whole-thorax irradiation at 12.75 Gy mid-lung for radiation pneumonitis

Switching to the AIN-76A diet after irradiation markedly reduced radiation nephropathy and non-significantly reduced pneumonitis morbidity, whereas switching before irradiation had no effect and the protein source did not matter.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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