Delayed Effects of Acute Radiation Exposure (Deare) in Juvenile and Old Rats: Mitigation by Lisinopril.
RatRadiationWAG/RijCmcr (Wistar)Female and malen = Juvenile females 13 versus 9; juvenile males 8 versus 7; ol…Oral, in drinking waterAbout 24 mg per m2 per day, delivered as 40 mg/L in drinkin…Started 7 days after irradiation
Model: 13 Gy leg-out partial-body irradiation with 320 kVp x-rays, with one hind limb shielded and the head additionally shielded in some old rats
Lisinopril mitigated radiation nephropathy in juvenile and old rats of both sexes and pneumonitis in juvenile females, raising juvenile survival from 0% to 88%, although old-rat survival curves did not differ.
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