Cardiac Remodeling and Reversible Pulmonary Hypertension During Pneumonitis in Rats after 13-Gy Partial-Body Irradiation with Minimal Bone Marrow Sparing: Effect of Lisinopril.
RatRadiationWAG/RijCmcrFemalen = Three independent sets totalling about 68 rats, with 4 to 1…Oral, in drinking waterAbout 24 mg per m2 per dayStarted 7 days after irradiation
Model: 13 Gy partial-body irradiation sparing one hind leg
Lisinopril prevented the transient pulmonary hypertension seen at 50 days and raised survival from 41% to 86%, but was associated with left ventricular remodelling at 50 days and signs of pulmonary hypertension by 100 days.
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