PRECLINICAL PUBLICATION · 2019

Serotonin 5-HT1A receptors modulate depression-related symptoms following mild traumatic brain injury in male adult mice.

Mouse / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

8-OH-DPAT (5-HT1A receptor agonist), with WAY-100635 (5-HT1A antagonist) as a comparator probe

PMID 30607822 ↗2019Reported benefit

Serotonin 5-HT1A receptors modulate depression-related symptoms following mild traumatic brain injury in male adult mice.

MouseTBIUnspecifiedMaleIntracerebroventricularSubthreshold dose, value not statedAfter injury induction

Model: Mild traumatic brain injury

Mild traumatic brain injury increased depression-like behaviour, which was reduced by a subthreshold dose of the 5-HT1A agonist 8-OH-DPAT and worsened by the antagonist WAY-100635.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.